The aim of this study was to examine general and dermatological quality of life, self-esteem, and frequency of using beauty filters on social networks. Participants of the study were people suffering from acne vulgaris who are being treated at the Department of Dermatology and Venereology of the Clinical Hospital Center Osijek. The sample consisted of N=75 participants aged between 15 and 30, 14 males and 61 females. Participants filled out Demographic Data Questionnaire, Disease Characteristics Questionnaire, Rosenberg Self-Esteem Scale (RSES), Dermatological Quality of Life Index (DLQI), Self-Assessment Scale of Subjective Quality of Life, and a question about the frequency of beauty filters use on social networks. The results indicated there is no statistically significant association between dermatological quality of life, self-esteem, and the use of beauty filters on social networks with demographic and disease characteristics, as well as no statistically significant association between the use of beauty filters and dermatological quality of life and self-esteem. A statistically significant association between dermatological and general quality of life and between dermatological quality of life and self-esteem was found and worse dermatological quality of life is associated with lower general quality of life and lower self-esteem. Also, a significant positive correlation was found between the general quality of life and self-esteem. Hierarchical regression analysis revealed that dermatological quality of life and self-esteem are significant predictors of general quality of life, with self-esteem being a mediator of the negative association between dermatological and general quality of life. Despite its shortcomings and limitations, this research provides new insights into the psychological aspect of acne vulgaris and predictors of the general quality of life in affected individuals.