The aim of this study was to examine the relationship between quality of life, social support and depression in postpartum woman within a few days after childbirth, and to check if there is a possiblity of predicting postpartum depression based on social supprot, quality of life domains, and some socio-demographic and health variables. Sample consisted of 101 post partum woman (N=101) located in the Department of Obstetrics and Gynecology General Count Hospital Vinkovci. The folowing instruments were used: WHOQOL-BREF to measure quality of life, Social support scale to assess perceived social support, Edinburgh postnatal depression scale (EPDS) to identify the presence of depressive symptoms and sociodemographic and health related variables questionnaire. The results indicate that there is a statistically significant relationship between social supprot and all of quality of life domains, except for physical health. The association between depression and overall quality of life and between depression and social relationships domain has not been established, while the depression is significantly negatively associated with the domains of physical and psychological health and the environment domain. The relationship between social support and depression is significant and negative. Socio-demographic and health variables, as well as perceived social support do not contribute significantly to the explanation of depression, while the only significant predictor was found to be mental health domain.