The aim of this research was to examine the relationship between alexithymia, neuroticism and estimated severity of psoriatic symptoms in patients. The study included 109 people diagnosed with psoriasis vulgaris.Toronto Alexithymia Scale was used to measure alexithymia (Toronto Alexithymia Scale, TAS-26, Taylor et al., 1985; according to Kocijan Lovko, Gelo, Karlović, 2015). Neuroticism was assessed by the neuroticism scale from The Big Five Inventory (John i Srivastava, 1999) and the disease severity was measured using the Psoriasis Area and Severity Index (Fredriksson, Pettersson, 1978). The analysis of variance and hierarchical regression analysis were used for estimation of the data. While determining direct contribution of personality traits to manifestations of psoriatic symptoms it is estimated that both personality traits, alexithymia as well as neuroticism, are directly related to the severity of psoriatic symptoms. Variable of neuroticism has proven to be a better predictor of criteria.Examination of different manifestations of clinical psoriatic symptoms considering the interaction between personality traits and gender show that there is a statistically significant interaction effect between gender and alexithymia.High-alexithymic women have the most pronounced symptoms of psoriasis compared to those of other groups of participants. On the other hand, the effect of interaction between neuroticism and gender has not been significant in terms of the prevalence of symptoms of this disease.