A growing number of people are faced with workplace stress and thus burnout syndrome. Although this phenomenon has been researched for decades, there is still uncertainty about its causes. Most of the literature focuses on organizational or occupational aspects, but it seems that other factors need to be included in this discussion too. Therefore, this thesis describes how personality and type of occupation can influence the occurrence of burnout syndrome. It has been shown that the dimensions of the five-factor personality model, mostly extroversion and neuroticism, can significantly predict the occurrence of burnout syndrome in employees. Likewise, the dark triad and other personality characteristics such as external locus of control and low self-esteem have an impact on the occurrence of job burnout. Furthermore, burnout syndrome is more common in some occupations. Many findings indicate a risk of burnout in the healthcare industry. Most research agrees that physicians, nurses, and technicians are highly susceptible to burnout due to extreme job requirements. Moreover, research also points to the risk of developing burnout syndrome within professions, such as psychotherapists, social workers, teachers, educators, and prison staff. However, the burnout phenomenon needs to be further investigated in these populations in order to draw an unambiguous conclusion. Finally, given that burnout syndrome is becoming an increasingly common health problem, the thesis also provides an overview of strategies to reduce the occurrence of this phenomenon in employees.