Recruitment of analogue astronauts is a challenging and crucial task in order to guarantee the success of any mission. One of the most important things to assess is emotional stability and the ability to make optimal decisions even under conditions of isolation. Previous findings have suggested that different factors of psychopathy (Fearless Dominance and Impulsive Antisociality) are connected to both of these outcomes. However, to the extent of our knowledge, this connection has never been explored in the context of analogue astronaut selection. The aim of this study was to determine the relationship across time between the above mentioned psychopathic factors with stress, anxiety and depression, and optimal risk decision making and risky behavior measured on the Balloon Analogue Risk Task (BART). The results were collected on 12 participants during the course of the analogue mission PMAS 2017. Using hierarchical linear modeling (HLM) we investigated the relationship of psychopathic factors and BART results across time. No significant relationship was found. In parallel HLM was also used to investigate the relationship of depression, anxiety and stress with different psychopathic factors. The positive relationship between Impulsive Antisociality with depression, anxiety and stress was found across time, as well as a negative relationship of Fearless Dominance with depression and stress. These results suggest possible advantages on considering a high ―Fearless Dominant‖ and low ―Impulsive antisociality‖ profile when considering candidates for highly emotionally demanding analogue missions as a simple, quick and economical addition to the existing selection process. Nevertheless, a more detailed overview of psychopathic factors in the selection of analogous astronauts is needed to show how differentiating factors of psychopathy can be of use in the present context.