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undergraduate thesis
Epigenetska osnova velikog depresivnog poremećaja
2017. urn:nbn:hr:142:938367
Mikulaj, Kornelija
Josip Juraj Strossmayer University of Osijek
Faculty of Humanities and Social Sciences
Depatrment of Psychology

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Mikulaj, K. (2017). Epigenetska osnova velikog depresivnog poremećaja (Undergraduate thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:142:938367

Mikulaj, Kornelija. "Epigenetska osnova velikog depresivnog poremećaja." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences, 2017. https://urn.nsk.hr/urn:nbn:hr:142:938367

Mikulaj, Kornelija. "Epigenetska osnova velikog depresivnog poremećaja." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences, 2017. https://urn.nsk.hr/urn:nbn:hr:142:938367

Mikulaj, K. (2017). 'Epigenetska osnova velikog depresivnog poremećaja', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences, accessed 19 March 2023, https://urn.nsk.hr/urn:nbn:hr:142:938367

Mikulaj K. Epigenetska osnova velikog depresivnog poremećaja [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences; 2017 [cited 2023 March 19] Available at: https://urn.nsk.hr/urn:nbn:hr:142:938367

K. Mikulaj, "Epigenetska osnova velikog depresivnog poremećaja", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences, Osijek, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:142:938367

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Metadata
TitleEpigenetska osnova velikog depresivnog poremećaja
Title (english)Epigenetic basis of Major depressive disorder
AuthorKornelija Mikulaj
MentorHrvoje Lepeduš (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Humanities and Social Sciences
(Depatrment of Psychology)
Osijek
Defense date and country2017-09-20, Croatia
Scientific / art field,
discipline and subdiscipline		SOCIAL SCIENCES
Psychology
Biological Psychology
Abstract
Veliki depresivni poremećaj (eng. Major Depressive Disorder; MDD) jedan je od najčešćih psihosomatskih poremećaja koji pokazuje izraženu tendenciju porasta, zbog čega se predviđa da bi do 2020. godine mogao postati drugi najveći zdravstveni svjetski problem. Klinička fenotipizacija depresivnog poremećaja vrlo je heterogena, što ukazuje na njegovu etiološku složenost. Mogući razlozi za ovakav ishod jesu ti što u etiologiji depresivnog poremećaja najvjerojatnije sudjeluje veliki broj gena s malim pojedinačnim doprinosom kliničkim fenotipovima. Rastući broj istraživanja u posljednjih 10-ak godina ukazuje na mogućnost da bi epigenetski mehanizmi regulacije genske ekspresije (međuovisne promjene obrazaca metilacije/demetilacije DNA molekule i acetilacije/deacetilacije histonskih proteina, te djelovanje različitih nekodirajućih molekula RNA), mogli imati ključnu ulogu u nastanku i liječenju ovog psihičkog poremećaja, kao poveznica između bioloških i ostalih čimbenika koji uzrokuju depresiju. Rezultati istraživanja pokazuju da mnogi antidepresivi koji se koriste u terapiji depresivnog poremećaja imaju direktni epigenetski učinak, čime se otvara potpuno novo poglavlje u razumijevanju patogeneze depresivnog poremećaja i učinkovitosti terapije antidepresivima. Također očekuje se i razvoj novih psihofarmaka čije bi se djelovanje temeljilo na epigenetskim modifikacijama visoko specifičnim za depresivni poremećaj, što bi omogućilo efikasniju terapiju i bolje praćenje učinka liječenja i eventualnih nuspojava.
Abstract (english)
Major Depressive Disorder (MDD) represents one of the most common psychosomatic disorder and it reveals the strong increase tendency. So, it would be expect to become second major world health problem by the year 2020. The clinical phenotyping of MDD reveals great heterogenety of MDD what points to its etiological complexity. Probable cause for such outcome was due to large number of genes with minor solitary contribution to MDD etiology and clinic phenotypes. Increasing number of MDD research during last decade indicated that epigenetic regulatory mechanisms of genes expression (mutual changes in methylation/de-methylation of DNA and histone acetylation/de-acetylation patterns on the other side, as well as the role of different noncoding RNA molecules) might have the crucial role in pathogenesis and healing this mental disorder, since they were highlighted as probable link between biological and other MDD causing factors. Further, it was shown that most of usually utilized antidepressants used in MDD therapy had direct epigenetic effects what open completely new chapter in the appreciation of the MDD pathogenesis and antidepressant performance. Correspondingly, the development of new psychoactive drugs that should have epigenetic action mechanism highly specific for MDD would enable much efficient therapy as well as better monitoring of its results and possible side-effects.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:142:938367
Study programmeTitle: Psychology (single major)
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) psihologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) psihologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2017-12-05 10:58:55